Scaling Your Site with WPMU\’s HyperDB Plugin
Trent just posted a wonderful article about configuring HyperDB. It is a replacement DB class to WordPress/’ standard database class WPDB. HyperDB is used by WordPress.com, GetShopped, and several other large, successful WPMU-based sites.
In essence, by using HyperDB, you can more easily scale a WPMU-based application by spreading your data across multiple database servers. If you have a site that has a real potential of growing very large and fast, you should investigate HyperDB and see if it is for you.
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