True, BuddyPress provides a way to upload avatars, and “Basic User Avatars” and “Simple Local Avatars” are plugins offering that feature. However, after upgrading my theme to HTML5 and removing Flash from my browser, I can no longer upload avatars using any of the three mentioned possibilities (backend or frontend).
As for your suggestion about Autoptimize, it does not work like that. “plupload.full.min.js” is supposed to be in the “exclude” list. This means Autoptimize does not dump the contents of plupload.full.min.js into a single JavaScript file. As long as plupload.full.min.js is excluded from Autoptimize, plupload.full.min.js is accessible by plugins that call it directly.