On a personal note, one thing I would like to see on BuddyPress is a complete Groups hierarchy with (multiple) parents, siblings and child groups. I reckon this would open a whole new market for things like geneology (big business).
Also I think you should take a good look at the rival product BuddyBoss, which, feature wise, is ahead of Buddypress in so many ways. A good media integration for example is a must have, likewise a file download system. BP could have the edge on its rival though, simply because the latter concentrates on Premium features.
Its easy to use yes Squirrel, but what it doesn’t do is solve the CSS issues, and that got too tricky. In the end it was easier to use a buddypress template and adapt it to my purposes