BuddyPress.org

The recommended method is to turn off other plugins and / or switch to a standard theme like WP 2015.
Due to permalinks aspect, I suspect another plugin.

If that doesn’t narrow it down, you can submit a bug ticket here.
But you should provide better instructions on how to duplicate the issue.
This is unclear: “To break the site navigate to the profile and page to another page/set of users and the page does an ajax call to load the view”