BuddyPress.org

Im having a very similar problem.

I have installed WordPress MU & Buddypress on a sub domain:

http://site.mydomain.com

When I login I can click on ‘My Account’ if I click ‘Edit Profile’ I get a 404 error. Any of the other my account options such as change signature or change avatar works OK.

Also noticed that if using the Album+ plugin, when I click upload a picture it does the upload but then immediatly shows a 404.

Assume this is related in some guise to the subdomain. Maybe WordPress/Buddypress is best left on the root?

Just installed:

WordPress MU 292

BuddyPress 123

IIS6 (Hosted/Helm) PHP 5