I think maybe I was unclear. Here is my set up with WordPress 3.0
http://www.mysite.com is a multisite installation. It’s also the blog page. I have a number of contributes who’s posts are either syndicated there via RSS or via Manual Posting.
I have a secondary site that i’ve used the domain mapping plugin in order to manage a separate domain. (www.mysite2.com) I DON’T want the Buddypress install on this site. Is that possible?